Key defender Esava Ratugolea will undergo an arthroscopy on his knee following an incident during Sunday's game.
Ratugolea received a heavy knock to the inside of his right knee, with scans on Monday showing damage to the meniscus.
Mid-season draftee Mani Liddy underwent an adductor release procedure on Monday to relieve discomfort he's been experiencing in recent weeks, while Connor Rozee had a successful surgery to repair his hamstring tendon last Wednesday.
The return to play timeline for Ratugolea, Liddy and Rozee will become clearer in the coming days.
Todd Marshall will miss Round 3 as he continues to rehabilitate an ankle sprain, while Miles Bergman will be tested this week and is expected to be available for Saturday's game.
Young forward Tom Cochrane will be available for selection following recovery from a pre-season hamstring injury.
Port Adelaide will name its team for Saturday's Round 4 clash against Richmond on Thursday at 5:50pm.
Injury list
Miles Bergman (ankle) - test
Jacob Moss (head/neck) - concussion protocols
Mani Liddy (groin) - TBC
Esava Ratugolea (knee) - TBC
Connor Rozee (hamstring) - TBC
Todd Marshall (ankle) - 1-2 weeks
Harrison Ramm (ankle) - 4-5 weeks
Sam Powell-Pepper (knee) - 7-9 weeks
Josh Sinn (shoulder) - 5 months
Ivan Soldo (knee) - season