Cameron Hitchcock has been sidelined with a hamstring injury, while Hamish Hartlett will miss the Power's next two games through suspension.
Nathan Blee has been omitted.
Match Preview
Into the side comes three smalls, headlined by the return of young pocket-rocket Jake Neade.
Neade has played in the SANFL for the last three weeks and has been in form worthy of a recall to the team, according to senior coach Ken Hinkley.
"Jake's had a good spell with three weeks back at SANFL level where it looks like he got his run back into his legs," Hinkley told portadelaidefc.com.au.
"We've been pretty keen to get him back into the side and a big, open ground at Perth gives us a good opportunity to do that."
Sam Colquhoun has slid straight back into the team lineup after being a late withdrawal from last Saturday's game against the Suns with back tightness.
"We took no risks with Sam last week, as a young player we weren't going to run the risk of further injury to him," said Hinkley.
Away match information
West Australian first-year player Kane Mitchell will return to the Power in front of a home crowd after a strong performance for Woodville-West Torrens in the SANFL last Saturday.
"He went back and played really well in the SANFL and was probably the best player in the team that day," said Hinkley.
"He did really well in a couple of different roles and adds to the run we bring back into the side."
Hinkley said the changes have been made to inject pace into the team against the defensive Dockers.
"All three boys add a significant amount of run to the team which we think we're going to need over there," said Hinkley.
Tom Logan will fly with the team as a travelling emergency.
Port Adelaide plays Fremantle at 5:40pm (AWST)/7:10pm (ACST) with full coverage during and after the game on portadelaidefc.com.au
Click here to see both teams
Port Adelaide Round 22 team v Fremantle
FB: Cameron O'Shea, Alipate Carlile, Campbell Heath
HB: Matthew Broadbent, Jackson Trengove, Tom Jonas
C: Brad Ebert, Travis Boak, Kane Cornes
HF: Robbie Gray, Justin Westhoff, Angus Monfries
FF: Jake Neade, Jay Schulz, Chad Wingard
Foll: Matthew Lobbe, Andrew Moore, Oliver Wines
Interchange from: Jasper Pittard, Sam Colquhoun, Kane Mitchell, Aaron Young
Emergencies: Lewis Stevenson, Ben Newton, Tom Logan
In: Sam Colquhoun, Kane Mitchell, Jake Neade
Out: Nathan Blee (omitted), Hamish Hartlett (suspended) Cameron Hitchcock (hamstring)
