The Port Adelaide midfielders have battled hip flexor and hamstring complaints respectively and were overlooked at the selection table.
General Manager - Football, Peter Rohde, said that the selection committee decided in favour of resting the pair to ensure their recovery progressed successfully.
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“Cassisi trained today, but didn’t feel confident to go flat out and I suppose we’re a bit wary - we just want to give him a chance to get it right.
“We know that if he comes back now and plays and hurts it again it’ll have a big impact on the rest of the year for him.”
“We’ve erred on the side of caution with both him and D-Rod.”
Rodan returned to the Power side in round 14 against Geelong but withdrew from last Saturday’s Balfours Showdown with concerns over his fitness.
“D-Rod’ had hamstring tightness in the Geelong game and last week he was feeling as though there was something wrong still there and he still hasn’t been able to reproduce 100% intensity,” said Rohde.
“We’ll give him another week and we’ll be fine and we won’t risk re-injuring it.
Port Adelaide takes on Essendon at 1.40pm on Saturday at AAMI Stadium.
Click here to view the selected side, including three omissions, to take on the Bombers.